These studies provided mechanistic insights into the antifibrotic properties of TMP that may be exploited as a potential option for hepatic fibrosis. These data collectively revealed that TMP modulation of ERK/p53 signaling led to mitochondrial-mediated and caspase-dependent apoptosis in HSCs in vitro. Moreover, TMP altered expression of some marker proteins relevant to HSC activation. Autodock simulations predicted that TMP could directly bind to ERK2 with two hydrogen bonds and low energy score, indicating that ERK2 could be a direct target molecule for TMP within HSCs. Mechanistic investigations revealed that TMP selectively blocked the extracellular signal-regulated kinase (ERK) signaling and activated p53, which was required for TMP induction of caspase-dependent mitochondrial apoptosis in HSCs. Furthermore, we found that TMP disrupted mitochondrial functions and led to activation of caspase cascades in HSCs. These effects were associated with TMP regulation of cyclin D1, p21, p27 and p53. Our results demonstrated that TMP had no apparent cytotoxic effects on hepatocytes, but significantly inhibited HSC proliferation and induced cell cycle arrest at the G0/G1 checkpoint. The present study aimed at investigating the anti-proliferative and pro-apoptotic effects of TMP on HSCs and elucidating the underlying mechanisms. However, the molecular mechanisms remain to be defined. Natural product tetramethylpyrazine (TMP) exhibits potent antifibrotic activities in vivo. Pharmacological induction of HSC apoptosis could be a promising strategy for fibrosis regression. We have updated the jaudiotagger music tagging library, this has over twenty fixes since the last Jaikoz release, and we have fixed a number of Jaikoz bugs recently reported by customers.Activation of hepatic stellate cells (HSCs) is a pivotal event in the pathogenesis of liver fibrosis. We also have modified the default settings of Jaikoz to better match the SongKong default profileĪdditionally we have added full support for release level performers, Discogs performers and Roon Recording Location and Dates to match SongKong Some customers use both applications and this meant that if you matched your library in SongKong and then updated them in Jaikoz some fields would get modified, then if you updated in SongKong they would get modified again, this release aims to eliminate this yo-yo ing. Jaikoz and SongKong have similar matching algorithms and support the same metadata fields, but they were doing things a bit differently. For managing and identifying the songs of your liking, SongKong is a reliable solution. There are many reasons why we think that SongKong is one of the best Shazam alternatives right now. Supporting both these features required updating a number of libraries and alot of code changes, we have other UI improvements on the way but don’t like to make too many drastic changes to the UI in a single release. SongKong is another one of those Shazam Alternatives that can give Shazam a good run for its money. Perhaps the most requested feature has now been done, we now support multiple-column sorting see Jaikoz and Multi Column Sorting - Jaikoz Announcements - SongKong and Jaikoz Music Tagger Community Forum for more details We now support the main view/edit table being multi tabbed so now you can view many fields without having to scroll to the right, the tabs are fully configurable and you can have as few or many as you like, see Jaikoz Main Edit Table is now Multi Tab - Jaikoz Announcements - SongKong and Jaikoz Music Tagger Community Forum for details. This release has three main areas of focus: Jaikoz is a great option if you like the idea of SongKongs automated matching but would like more control over your tagging, and we continue to provide a 20% discount on Jaikoz Pro, just enter JAIKOZWITHROON as promo code We have a new version of Jaikoz, Jaikoz 11.1 Hole full details can be found here Improves the metadata to allow Roon to identify albums it could not previouslyĬan also reorganize folder structure to put split albums back into one album = one folder to help Roon identify.Īdds additional metadata for albums that Roon could identify but has limited informationĪdds metadata for albums that Roon still cannot identify so they display better in Roon Roon cannot always identify all your music, especially if your music includes partial albums or invalid metadata. Roon is a great application for playing your music, but Jaikoz music tagging features can make it even better, and like Roon we really care about metadata. The good news is I have now added the same Roon support to Jaikoz as well Or you may be aware of the SongKong Music Tagger, this is a fully automated tagger with extensive Roon support. Hi, you may already aware of Jaikoz Music Tagger, a comprehensive automatic and manual editing tagger available for MacOS,Windows and and Linux.
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